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Genetics & Genomics

Gene Expression Helps Predict Benefit From Adjuvant Chemo for Breast Cancer

Although nearly 60% of all patients with early-stage breast cancer are given adjuvant chemotherapy, only 2%–15% of them receive clinical benefit, according to research published in the 2016 American Society of Clinical Oncology Educational Book.

October 18, 2016

Palbociclib Plus Letrozole Improves Survival in Advanced Breast Cancer

A study presented at the 2016 ASCO annual meeting confirmed findings that led to the U.S. Food and Drug Administration approval of palbociclib in combination with letrozole for first-line treatment in women with estrogen receptor -positive, HER2-negative advanced breast cancer.

October 11, 2016

Why More Women Are Choosing Bilateral Mastectomies

In just seven years, the rates of women who received prophylactic bilateral mastectomies after a diagnosis of unilateral breast cancer skyrocketed—though many don't require bilateral mastectomy. So what’s causing the increase in unnecessary surgery?

October 11, 2016

Neratinib May Be Effective for HER2-Positive Breast Cancer

According to the results of a phase II, randomized study published in the New England Journal of Medicine, neratinib may effectively treat women with HER2-positive, hormone receptor-negative breast cancer.

October 04, 2016

Weight Gain May Indicate Clinical Benefit in NSCLC

Increasing weight during treatment may indicate early clinical benefit in patients with non-small cell lung cancer (NSCLC), according to the results of a study published in the Annals of Oncology.

September 27, 2016

Genetics & Genomics

Thyroid Cancer Treatment’s Changing Landscape Brings New Hope to Patients

Until 2011, no effective therapeutic options existed for advanced thyroid cancer. However, thanks to clinical studies that have improved the understanding of thyroid cancer’s molecular basis, four kinase inhibitors were approved by the U.S. Food and Drug Administration.

September 27, 2016

Cancer Treatments

Inotuzumab Ozogamicin May Improve Survival in ALL

Researchers have found that a monoclonal antibody called inotuzumab ozogamicin may help more patients with refractory B-cell acute lymphoblastic leukemia (ALL) proceed to stem cell transplantation. The findings were reported in the New England Journal of Medicine.

September 20, 2016

MABp1 May Be Effective for Metastatic Colorectal Cancer

A new immunotherapy drug, MABp1, is the first to target interleukin-1 alpha and may be effective in patients with metastatic colorectal cancer. The study results were presented at the World Congress of Gastrointestinal Cancer in Barcelona, Spain.

September 13, 2016

An Oncology Nursing Overview of New Immune Checkpoint Inhibitors

Immunotherapy has led to many new cancer treatments over the past several years and continues to offer increased options and better survival for patients. Oncology nurses need to have an understanding of how these therapies work and how to best manage patients’ side effects.

September 13, 2016

Cancer Screening

Metastatic Prostate Cancer Increasing in United States

The number of new U.S. cases of metastatic prostate cancer increased by 72% from 2004–2013, according to a new study published in Prostate Cancer and Prostatic Diseases.

September 06, 2016

Oncology Drug Research

Maintenance Treatment May Prolong Progression-Free Survival in Ovarian Cancer

Although response rates to chemotherapy are high, 90% of ovarian cancers will recur within two years. A new drug called niraparib is under investigation as maintenance treatment between cycles of platinum-based chemotherapy, and findings from phase III trials have shown promise.

August 23, 2016

Surgery Prolongs Survival for Patients With NSCLC

Patients with late-stage non-small cell lung cancer who have surgery have better survival rates than those who don’t, according to the results of a recent study published in the Annals of Thoracic Surgery. The researchers also reported that despite the improved survival from surgery, fewer patients are receiving the treatment.

August 23, 2016

Cancer Treatments

Poliovirus May Be Key to Treating Glioblastoma

A phase I study has shown that a small group of patients with recurrent glioblastoma who received treatment with a modified form of poliovirus showed survival improvement over historical controls. The findings, which were not peer reviewed, were presented at the 2016 American Society of Clinical Oncology annual meeting.

August 16, 2016

Cancer Treatments

Pembrolizumab Associated With Long-Term Survival in Advanced Melanoma

A new study has shown that 40% of patients with previously treated advanced melanoma were alive at three years’ follow-up after initiating treatment with pembrolizumab. The results were presented at the 2016 American Society of Clinical Oncology annual meeting.

August 09, 2016

Aerobic and Resistance Exercise May Reduce Comorbidities in Cancer Survivors

Although patients are living longer into survivorship, their comorbid burden is increasing. Studies have shown that survivors have increased rates of chronic disease, like type-2 diabetes and cardiovascular disease; and obesity compared to adults without cancer.

August 09, 2016

Pretreatment Anemia Predicts Poor Survival From NSCLC

Patients receiving stereotactic body radiation therapy for early-stage non-small cell lung cancer who have anemia at diagnosis may be more likely to have aggressive disease with poor survival and non-local progression, according to findings from a new study published in the Journal of Thoracic Oncology.

August 02, 2016

Oncology Drug Research

New Class of Drugs Shows Promise in Treatment-Resistant Prostate Cancer

Researchers in the United Kingdom are looking at a new class of drugs that attacks cancer indirectly through a network of signals, which may prevent or overcome drug resistance. The findings of the study were published in Cancer Research.

Sorafenib Adverse Events May Be More Common in Thyroid Cancer

Researchers have found that patients receiving sorafenib for differential thyroid cancer are more likely to experience adverse events from the drug, compared to patients with renal or hepatocellular cancers. The findings were published in JAMA Oncology.

Prostate Cancer

Prostate Radiotherapy May Increase Bladder Cancer Risk

Patients with prostate cancer who undergo radiation treatment, especially brachytherapy, may be at increased risk of bladder cancer more than 10 years later, according to the results of a new study presented at the American Urological Association annual meeting.

What Nurses Need to Know About Talimogene Laherparepvec for Advanced Melanoma

A number of different oncolytic immunotherapies are in development for advanced melanoma, one of which is talimogene laherparepvec, a genetically modified recombinant herpes simplex virus type 1.

Quality Measures May Lengthen Survival in NSCLC

Researchers have found that four quality measures (neoadjuvant multiagent chemotherapy, lobectomy or greater resection, sampling of at least 10 lymph nodes, and R0 resection) are associated with longer survival in patients with stage IIIA non-small cell lung cancer.

Blinatumomab May Induce Remission in Patients With Relapsed or Refractory ALL

About 40% of acute lymphocytic leukemias (ALLs) occur in adults, but those cases are responsible for 80% of ALL’s death rate. Two studies have shown the blinatumomab is effective in inducing remissions in refractory B-cell ALL.

Pancreatic Cancer

Protein May Offer Drug Target for Pancreatic and Other Cancers

Renalase, a protein that researchers have found is overexpressed in pancreatic cancer, may be a new key to treating the disease. The findings were reported in Scientific Reports.

Clinical Practice

Manage Common Ocular Toxicities From Tyrosine Kinase Inhibitors

Alopecia, rash, peripheral neuropathy: it’s a well-known fact that systemic cancer therapies often damage healthy tissues while fighting cancer cells. However, ocular toxicity from newer molecularly targeted cancer agents such as tyrosine kinase inhibitors (TKIs) is generally underestimated and under-reported.

Cancer Treatments

Radiation Plus Chemotherapy Improves Survival From Low-Grade Gliomas

A new study has shown that patients with grade 2 gliomas who are treated with radiation therapy plus a combination of chemotherapy have better survival than patients treated with radiation alone. The findings were published in the New England Journal of Medicine.

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To report a content error, inaccuracy, or typo, email pubONSVoice@ons.org.

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Elisa Becze BA, ELS, Editor

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