Among all racial and ethnic groups, indigenous people (Native American and Alaska Natives) had the largest decline in life expectancy from 2020–2021. They also have the lowest overall life expectancy (65.2 years) than any of their Asian, Black, Hispanic, or White counterparts—in some cases, up to 20 years shorter. Indigenous people have disproportionately high rates of suicide, chronic liver disease, cardiac disorders, diabetes, and infant and maternal mortality.