On June 21, 2024, the U.S. Food and Drug Administration (FDA) granted accelerated approval to adagrasib (Krazati^®) plus cetuximab for adults with KRAS G12C-variant locally advanced or metastatic colorectal cancer, as determined by an FDA-approved test, who have received prior treatment with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy.

Confounding researchers and clinicians alike, colorectal cancer rates are dramatically increasing among younger populations. In the latest study results published in Gastroentrology, researchers quantified the drastic shift of colorectal cancer diagnoses in various young groups aged 10–24 years.