Certain genetic variants can increase an individual’s risk for prevalent or persistent human papillomavirus (HPV) infections and the subsequent potential to develop cervical cancer, researchers reported in study findings published in the European Journal of Human Genetics. They identified three variants that increased an individual’s risk for HPV and one that lowered their risk.

On April 29, 2024, the U.S. Food and Drug Administration (FDA) granted traditional approval to tisotumab vedotin-tftv (Tivdak^®) for recurrent or metastatic cervical cancer with disease progression on or after chemotherapy. Tisotumab vedotin-tftv previously received accelerated approval for the indication.

In stark contrast to a nationwide decline, cervical cancer incidence and mortality rates are increasing in low-income U.S. counties, researchers reported in the International Journal of Cancer.

On January 12, 2024, the U.S. Food and Drug Administration (FDA) approved pembrolizumab (Keytruda^®) with chemoradiotherapy for patients with FIGO 2014 stage III–IVA cervical cancer.

Nearly a quarter of patients who are eligible for cervical cancer screening are overdue for their current tests, researchers said in study findings published in JAMA Network Open. The number grew nearly 10% since 2005—representing a steady increase in missed screening over time—and was higher in different sociodemographic groups because of factors related to social determinants of health.

In clinical trials, 24% of patients achieved an objective response rate with tisotumab vedotin-tftv (Tivdak^TM) that lasted a median of 8.3 months, leading to the agent’s U.S. Food and Drug Administration September 2021 approval for use in adults with recurrent or metastatic cervical cancer with disease progression on or after chemotherapy.

Multimedia tools and resources can help patients learn more about a cancer diagnosis, treatment regimens, procedures, and follow-up care, among other important topics, and many institutions and organizations have jumped onto the bandwagon to create those resources for their patients. A new video series on gynecologic cancers from the Centers for Disease Control and Prevention (CDC) adds another patient education resource to oncology nurses’ toolbox.

On October 13, 2021, the U.S. Food and Drug Administration (FDA) approved pembrolizumab (Keytruda^®) in combination with chemotherapy, with or without bevacizumab, for patients with persistent, recurrent, or metastatic cervical cancer whose tumors express PD-L1 (CPS ≥ 1), as determined by an FDA-approved test. 

On September 20, 2021, the U.S. Food and Drug Administration (FDA) granted accelerated approval to tisotumab vedotin-tftv (Tivdak™), a tissue factor-directed antibody and microtubule inhibitor conjugate, for adult patients with recurrent or metastatic cervical cancer whose disease has progressed on or after chemotherapy.

Only 4%–9% of patients with ovarian or cervical cancer use palliative care, but the numbers are much lower for Hispanic and Asian women than for non-Hispanic White women, according to researchers’ findings reported in Data in Brief.

People with a cervix who are aged 25–65 years should receive a human papillomavirus (HPV) test every five years, according to the new American Cancer Society (ACS) guidelines for cervical cancer screening.

Cervical cancer rates have dropped more than 90% among women who received the human papillomavirus (HPV) vaccine, according to the results of a Swedish study published in the New England Journal of Medicine. Global health leaders are calling it a milestone study. 

In 2020, approximately 13,800 new cases of invasive cervical cancer will be diagnosed in the United States. Prevention and screening are critical to reducing its incidence, and the U.S. Department of Health and Human Services (HHS) launched an awareness campaign in January in recognition of Cervical Health Awareness Month. The movement educates women about cervical cancer risks, how and when to get the human papillomavirus (HPV) vaccine, the vaccine’s impact on cancer rates, and how to promote awareness.

New cancer prevention strategies like the human papillomavirus (HPV) vaccine are making waves throughout the United States and around the world. Evidence has shown that the vaccine can help protect against certain cancers such as cervical, anal, oropharyngeal, penile, vulvar, and vaginal in people who receive the vaccine. For the first time ever, the World Health Organization (WHO) has global data outlining HPV coverage in countries across the globe.  

Recent congressional hearings about vaccination have caused a litany of responses from different members of the public, private, and political sectors. Current Centers for Disease Control and Prevention (CDC) evidence has shown that human papillomavirus (HPV) vaccination has led to fewer cases of HPV-related cancers.  

Not that long ago, women were told to get a Pap test every year. And most of us did, even though it wasn’t always clear why we were being tested. We just did what we were told and thought it was a surefire way to stay healthy. But times and recommendations have changed about what test to have, how often to have it, and the reason to have it. 

An S5 methylation test detected 100% of grade 2 cervical intraepithelial neoplasms or worse, compared to a 50% detection rate for Pap or human papillomavirus (HPV) tests, according to the results of a recent study reported in the International Journal of Cancer.

Pap tests have long been the gold standard to screen women for cervical cancer, but a new study published in JAMA says that in women older than 30 years, HPV testing is less invasive and more accurate.  

January was cervical health awareness month, and the federal government, along with many advocacy groups, spent considerable time talking about early detection. According to the National Cancer Institute and the U.S. Food and Drug Administration (FDA), cervical cancer is largely preventable. If it’s detected early, it’s often curable too. Many experts say that the key to cervical cancer is vaccination and embracing the two tests used for early detection—Pap smears and human papillomavirus (HPV) testing.