Oncology Drug Reference Sheet: Entrectinib

January 21, 2020 by Kathleen Sacharian MSN, CRNP

Entrectinib (Rozlytrek™) was approved by the U.S. Food and Drug Administration in August 2019 as the third tumor-agnostic cancer drug, meaning it targets a specific mutation of the cancer, not the organ of origin. The other two currently approved tumor-agnostic drugs are larotrectinib and pembrolizumab.

Category/Class

Entrectinib is a kinase inhibitor (https://www.gene.com/download/pdf/rozlytrek_prescribing.pdf)

Indication

The drug is indicated for the treatment of adults with ROS1-positive, metastatic, non-small cell lung cancer. It’s also indicated for adult and pediatric patients 12 years old and older with metastatic or unresectable solid tumors that have a NTRK gene fusion without a known acquired resistance mutation that have progressed following treatment or have no alternative treatment options.

Dosing

Administer 600 mg orally once daily. Dose reductions are recommended for certain adverse events (e.g., hematologic toxicity, cardiotoxicity, central nervous system [CNS] toxicity, hyperuricemia, hepatotoxicity). Discontinue permanently if adverse events persist after two dose reductions. Refer to the package insert for additional recommendations. Avoid concomitant use with strong or moderate CYP3A inhibitors; dose reduce if unavoidable.

Administration

Take orally with or without food but avoid grapefruit products. Make up a missed dose unless the next dose is within 12 hours.  

Adverse Reactions

The most common side effects are fatigue, constipation, dysgeusia, edema, dizziness, diarrhea, nausea, dysesthesia, dyspnea, myalgia, cognitive impairment, weight gain, vomiting, pyrexia, arthralgia, and vision disorders. Hematologic effects (e.g., anemia, lymphocytopenia, neutropenia) or cardiac effects (e.g., heart failure, QTc interval prolongation) have been reported. Approximately 25% of patients report CNS effects (e.g., cognitive impairment, mood disorders, dizziness, sleep disturbances), typically within three months of initiation. Skeletal fractures, vision changes, and hepatic toxicity have also been reported.

Nursing Considerations

Assess patients’ NTRK gene fusion status or ROS1 rearrangement status prior to initiation. Monitor lab values, including complete blood count, electrolytes, liver function tests, and uric acid. Consider LVEF for patients with history or symptoms of heart failure. Assess QTc interval at baseline and periodically. Monitor for CNS adverse effects, tumor lysis syndrome, and hepatotoxicity. These or other clinically relevant adverse events may require holding the drug or dose reduction. Assess for concomitant drugs such as moderate and strong CYP3A inducers or drugs that prolong QT interval. Because of the potential for fetal harm, exclude pregnancy prior to initiation and ensure patients use ongoing effective contraception.

Patient Education 

Gero-Oncology Considerations

Clinical studies did not include sufficient numbers of older adults to determine whether they respond differently.

Safe Handling

Because of the known embryo-fetal toxicity following exposure to entrectinib, nurses should use hazardous drug precautions when handling.

Patient Assistance Program

A financial assistance program is available at the manufacturer’s website (https://www.rozlytrek.com/ros1-mnsclc/support-and-resources/financial-help.html).


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